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A Review of Acupuncture in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Received: 11 December 2018     Published: 12 December 2018
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Abstract

Multiple sclerosis (MS) is considered an incurable inflammatory demyelinating disease of the central nervous system around the world, which damages motor, sensory and autonomic nervous function, and has the characteristics of high recurrence rate and disability rate. Treatment strategy of MS in the world is dominated by glucocorticoid and disease-modify treatments (DMTs). However, due to the shortage of drugs, expensive price, poor response to treatment, obvious side effects and so on, it gradually becomes a common goal of Chinese and Western medicine research, that we must actively explore more effective and optimal treatment strategies to control the recurrence of MS, improve neurological function disability and patient’s quality of life. Clinical reports in recent years have demonstrated that acupuncture has these characteristics of improving neurological disability, reducing fatigue, improving gait abnormality and spasm, alleviating pain, improving bladder function damage, preventing recurrence and improving whole health status in treating MS. It may become a potential ideal complementary and alternative therapy for MS. However, there are relatively few studies on the mechanism of acupuncture treatment of MS and lack of high grade evidence to support it. Undoubtedly, it’s clinical application is limited. Experimental autoimmune encephalomyelitis (EAE) model is a common animal model to study the pathophysiological mechanism of MS and evaluate the efficacy of drugs. Experimental evidences show that acupuncture intervention EAE can regulate the secretion of related immune cells and inflammatory factors, alleviate nerve injury and promote nerve rehabilitation. Therefore, in this review, we will retrospect and summarize the recent advances in acupuncture treatment of MS and EAE. So that we can understand the mechanism of acupuncture intervention in MS/EAE better, as well as provide evidence and new perspective for further clinical and scientific research in the future.

Published in Science Discovery (Volume 6, Issue 6)
DOI 10.11648/j.sd.20180606.32
Page(s) 514-520
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Acupuncture, Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Review

References
[1] Bernitsas E. Pathophysiology and Imaging Diagnosis of Demyelinating Disorders [J]. Brain Sci,2018,8(3):1-3.
[2] 李海峰.多发性硬化2017版McDonald诊断标准的修订背景、内容及意义 [J].中国神经精神疾病杂志,2018,44(6):321-330.
[3] Lemus H N, Warrington A E, Rodriguez M. Multiple Sclerosis: Mechanisms of Disease and Strategies for Myelin and Axonal Repair [J]. Neurol Clin,2018,36(1):1-11.
[4] Devasahayam A J, Downer M, Ploughman M. The effects of aerobic exercise on the recovery of walking ability and neuroplasticity in people with multiple sclerosis: a systematic review of animal and clinical studies [J]. Mult Scler Int,2017,2017(4):1-12.
[5] 胡学强,常艳宇.我国多发性硬化诊治现状与进展 [J].重庆医科大学学报,2017(6):669-671.
[6] Huybregts E, Betz W, Devroey D. The use of traditional and complementary medicine among patients with multiple sclerosis in Belgium [J]. J Med Life,2018,11(2):128-136.
[7] Karpatkin H I, Napolione D, Siminovichblok B. Acupuncture and Multiple Sclerosis: A Review of the Evidence [J]. Evid Based Complement Alternat Med,2014(2):972935.
[8] 王春琛,陈志刚,王麟鹏.国际针刺治疗多发性硬化的证据分析与评价 [J].世界中医药,2016,11(11):2437-2440.
[9] 彭真,张礼标,吴洁,等.多发性硬化动物模型研究进展 [J].动物医学进展,2017,38(4):108-112.
[10] 中华医学会神经病学分会神经免疫学组.多发性硬化诊断和治疗中国专家共识(2014版) [J].中华神经科杂志,2015,48(5):362-367.
[11] Potter K, Cohen E T, Allen D D, et al. Outcome measures for individuals with multiple sclerosis: recommendations from the American Physical Therapy Association Neurology Section task force [J]. Phys Ther,2014,94(5):593-608.
[12] 汪瑛,汪节. “独取阳明”针刺治疗多发性硬化临床观察[C]//针灸甲乙经学术思想国际研讨会.2012.
[13] 李呈新.针刺背俞穴治疗多发性硬化24例 [J].针灸临床杂志,2013,29(4):42-44.
[14] 丁宇,石现.电针结合穴位注射治疗多发性硬化对照研究 [J].中国针灸,2013,33(9):793-795.
[15] 罗友余.电针结合穴位注射治疗多发性硬化对照研究 [J].实用中西医结合临床,2015,15(2):37-38.
[16] 隋瑞峤,邹伟.针刺治疗缓解期多发性硬化症24例 [J].上海针灸杂志,2016,35(3):332-333.
[17] Fiest K M, Fisk J D, Patten S B, et al. Fatigue and Comorbidities in Multiple Sclerosis [J]. Int J MS Care. 2016,18(2):96-104.
[18] Patejdl R, Penner I K, Noack T K, et al. Multiple sclerosis and fatigue: A review on the contribution of inflammation and immune-mediated neurodegeneration [J]. Autoimmun Rev,2015,15(3):210-220.
[19] 陈克龙,樊永平.多发性硬化患者的疲劳状况及其影响因素 [J].温州医科大学学报,2017,47(1):52-55.
[20] Rosti‐Otajärvi E, Wiksten A, Hakkarainen T, et al. Validity and reliability of the Fatigue Severity Scale in Finnish multiple sclerosis patients [J]. Brain Behav, 2017,7(7):e00743.
[21] Heine M, Akker L E V D, Blikman L, et al. Real-Time Assessment of Fatigue in Patients With Multiple Sclerosis: How Does It Relate to Commonly Used Self-Report Fatigue Questionnaires? [J]. Arch Phys Med Rehabil,2016,97(11):1887-1894.
[22] Foell J. Does acupuncture help in helping the ones you cannot help? The role of acupuncture in facilitating adaptive processes [J]. Acupunct Med,2011,29(1):61-64.
[23] Foroughipour M, Bahrami Taghanaki H R, Saeidi M, et al. Amantadine and the place of acupuncture in the treatment of fatigue in patients with multiple sclerosis: an observational study [J]. Acupunct Med,2013,31(1):27-30.
[24] 李康宁,樊永平,王文明,等.针刺对复发-缓解型多发性硬化患者疲劳的疗效评价及对血清白细胞介素1β和肿瘤坏死因子α的影响 [J].环球中医药, 2016,9(8):1024-1026
[25] Larocca N G. Impact of walking impairment in multiple sclerosis: perspectives of patients and care partners [J]. Patient,2011,4(3):189-201.
[26] Mehanna R, Jankovic J. Movement disorders in multiple sclerosis and other demyelinating diseases [J]. J Neurol Sci,2013,328(1–2):1-8.
[27] Criado M B, Santos M J, Machado J, et al. Effects of Acupuncture on Gait of Patients with Multiple Sclerosis [J]. J Altern Complement Med. 2017,23(11):852-857.
[28] 滕日添.痉挛的临床康复治疗 [J].健康必读旬刊,2011(10):375-375.
[29] Heinzlef O, Monteil-Roch I. Pharmacological treatment of spasticity in multiple sclerosis [J]. Rev Neurol (Paris).2012,168 Suppl 3:S62-68.
[30] Zhao J, Cao C C, Han B, et al. Effect of acupuncture treatment on spastic states of stroke patients [J]. Journal of the Neurological Sciences,2009,276(1–2):143-147.
[31] 汪军,崔晓.针刺治疗痉挛研究进展 [J].中国康复医学杂志,2012,27(2):191-193.
[32] Miller M R E. An investigation into the management of the spasticity experienced by some patients with multiple sclerosis using acupuncture based on traditional Chinese medicine [J]. Complement Ther Med,1996, 4(1):58-62.
[33] Murphy K L, Bethea J R, Fischer R. Neuropathic Pain in Multiple Sclerosis—Current Therapeutic Intervention and Future Treatment Perspectives [M]// Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. 2017.
[34] 方剑乔,邵晓梅.针刺镇痛的新思路-针灸参与疼痛多维度调节的可行性 [J].针刺研究,2017,42(1):85-89.
[35] Lee H, Park H J, Park J, et al. Acupuncture application for neurological disorders [J]. Neurol Res. 2007,29 Suppl 1:S49-54.
[36] Tajik A, Dabiran S, Soltanzadeh A, et al. Efficacy of Acupuncture in the Treatment of Chronic Pain and Fatigue in Patients with Multiple Sclerosis [J]. Journal of Isfahan Medical School,2012,30(202):1.
[37] Kopsky D J, Hesselink J M. Multimodal stepped care approach with acupuncture and PPAR-α agonist palmitoylethanolamide in the treatment of a patient with multiple sclerosis and central neuropathic pain [J]. Acupunct Med. 2012,30(1):53-55.
[38] Zelaya J E, Murchison C, Cameron M. Associations Between Bladder Dysfunction and Falls in People with Relapsing-Remitting Multiple Sclerosis [J]. Int Neurourol J. 2015,19(4):272–277.
[39] Zelaya J E, Murchison C, Cameron M. Associations Between Bladder Dysfunction and Falls in People with Relapsing-Remitting Multiple Sclerosis [J]. Int Journal Ms Care,2017,19(4):184–190.
[40] Sh T E S, Kopsky D J, Jongen P J, et al. Multiple sclerosis patients with bladder dysfunction have decreased symptoms after electro-acupuncture [J]. Mult Scler. 2009,15(11):1376-1377.
[41] 郑燕芳,王淑英,张向英,等.针刺联合艾灸治疗多发性硬化神经源性膀胱46例临床观察 [J].河北中医,2015(8):1208-1210.
[42] 王春琛,陈志刚,马昕宇.金针王乐亭经验方治疗缓解期复发缓解型多发性硬化8例的临床观察 [J].世界中医药,2017(9):2114-2117.
[43] 王春琛,陈志刚,王麟鹏,等.针刺治疗缓解期复发缓解型多发性硬化症:随机对照研究 [J].中国针灸,2017,37(6):576-580.
[44] Skovgaard L, Nicolajsen P H, Pedersen E, et al. Use of Complementary and Alternative Medicine among People with Multiple Sclerosis in the Nordic Countries [J]. Autoimmune Dis,2012(5):841085.
[45] 刘立飞,刘学军,徐静.温针灸配合穴位注射治疗多发性硬化1例 [J].上海针灸杂志,2011,30(7):503-503.
[46] Quispe-Cabanillas J G, Damasceno A, Glehn F V, et al. Impact of electroacupuncture on quality of lifefor patients with Relapsing-Remitting Multiple Sclerosis under treatment with immunomodulators: A randomized study [J]. BMC Complement Altern Med,2012,12(1):209.
[47] Hao J J, Cheng W, Liu M, et al. Treatment of Multiple Sclerosis With Chinese Scalp Acupuncture [J]. Glob Adv Health Med. 2013,2(1):8-13.
[48] 许军峰.针灸结合中药治疗多发性硬化症一例 [J].中华针灸电子杂志,2013,42(5):248-249.
[49] 汪海燕,毛忠南,毛立亚,等.浅谈多发性硬化的针刺治疗体会[C]//甘肃省中医药学会2013年学术年会.2013.
[50] 寇鹏,石学敏. “醒脑开窍”针刺法配合中药治疗多发性硬化1例报告 [J].湖南中医杂志,2015,31(4):124-124.
[51] 王建文,黄生辉,樊树银,等.温通针刺疗法治疗痰瘀痹阻型多发性硬化临床研究 [J].新中医,2016(5):129-131.
[52] 刘汉东,张智龙.张智龙针刺治疗多发性硬化验案1则 [J].湖南中医志,2017,33(3):105-106.
[53] Yun C, Li S, Xie Z, et al. Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications [J]. J Neurosci Res,2017,95(10):1973-1983.
[54] Hans Lassmann, Monika Bradl. Multiple sclerosis: experimental models and reality [J]. Acta Neuropathol,2017,133(2):1-22.
[55] 易锦,刘燕青,李倩,等.电针对实验性自身免疫性脑脊髓炎大鼠急性期脑组织IFN-γ、IL-4含量的影响 [J].武警医学,2009,20(11):991-993.
[56] Liu Y M, Liu X J, Bai S S, et al. The effect of electroacupuncture on T cell responses in rats with experimental autoimmune encephalitis [J]. J Neuroimmunol,2010,220(4):203-203.
[57] Liu Y, Wang H, Wang X, et al. The mechanism of effective electroacupuncture on T cell response in rats with experimental autoimmune encephalomyelitis [J]. Plos One,2013,8(1):e51573.
[58] Huang S F, Ding Y, Ruan J W, et al. An experimental electro-acupuncture study in treatment of the rat demyelinated spinal cord injury induced by ethidium bromide [J]. Neurosci Res,2011,70(3):294-304.
[59] Kim K Y, Yang W J, Shin T K, et al. Impact of acupuncture by using life-energy (qi) oriental needle on the paralysis of rats with experimental autoimmune encephalomyelitis [J]. Am J Chinese Med,2012,40(04):769-778.
[60] Auricchio F, Scavone C, Cimmaruta D, et al. Drugs approved for the treatment of Multiple Sclerosis: review of their safety profile [J]. Expert Opin Drug Saf. 2017,16(12):1359-1371.
[61] Ding SS, Hong SH, Wang C, et al. Acupuncture modulates the neuro-endocrine-immune network [J]. QJM,2014,107(5):341-345.
[62] ZhangJin Zhang, XiaoMin Wang, Grainne M. McAlonan. Neural Acupuncture Unit: A New Concept for Interpreting Effects and Mechanisms of Acupuncture [J]. Evid Based Complement Alternat Med,2012,2012:429412.
[63] Claflin S B, Mei I A F V D, Taylor B V. Complementary and alternative treatments of multiple sclerosis: a review of the evidence from 2001 to 2016 [J]. J Neurol Neurosurg Psychiatry, 2018,89(1):34-41.
[64] Yadav V, Bever C, Bowen J, et al. Summary of evidence-based guideline: Complementary and alternative medicine in multiple sclerosis Report of the Guideline Development Subcommittee of the American Academy of Neurology [J]. Neurology,2014,83(16):1083-1092.
Cite This Article
  • APA Style

    Dong Sha, Li Qi, Zhao Dongjie, Wang Yuhua, Xin Suicheng. (2018). A Review of Acupuncture in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Science Discovery, 6(6), 514-520. https://doi.org/10.11648/j.sd.20180606.32

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    ACS Style

    Dong Sha; Li Qi; Zhao Dongjie; Wang Yuhua; Xin Suicheng. A Review of Acupuncture in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Sci. Discov. 2018, 6(6), 514-520. doi: 10.11648/j.sd.20180606.32

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    AMA Style

    Dong Sha, Li Qi, Zhao Dongjie, Wang Yuhua, Xin Suicheng. A Review of Acupuncture in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Sci Discov. 2018;6(6):514-520. doi: 10.11648/j.sd.20180606.32

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  • @article{10.11648/j.sd.20180606.32,
      author = {Dong Sha and Li Qi and Zhao Dongjie and Wang Yuhua and Xin Suicheng},
      title = {A Review of Acupuncture in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis},
      journal = {Science Discovery},
      volume = {6},
      number = {6},
      pages = {514-520},
      doi = {10.11648/j.sd.20180606.32},
      url = {https://doi.org/10.11648/j.sd.20180606.32},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20180606.32},
      abstract = {Multiple sclerosis (MS) is considered an incurable inflammatory demyelinating disease of the central nervous system around the world, which damages motor, sensory and autonomic nervous function, and has the characteristics of high recurrence rate and disability rate. Treatment strategy of MS in the world is dominated by glucocorticoid and disease-modify treatments (DMTs). However, due to the shortage of drugs, expensive price, poor response to treatment, obvious side effects and so on, it gradually becomes a common goal of Chinese and Western medicine research, that we must actively explore more effective and optimal treatment strategies to control the recurrence of MS, improve neurological function disability and patient’s quality of life. Clinical reports in recent years have demonstrated that acupuncture has these characteristics of improving neurological disability, reducing fatigue, improving gait abnormality and spasm, alleviating pain, improving bladder function damage, preventing recurrence and improving whole health status in treating MS. It may become a potential ideal complementary and alternative therapy for MS. However, there are relatively few studies on the mechanism of acupuncture treatment of MS and lack of high grade evidence to support it. Undoubtedly, it’s clinical application is limited. Experimental autoimmune encephalomyelitis (EAE) model is a common animal model to study the pathophysiological mechanism of MS and evaluate the efficacy of drugs. Experimental evidences show that acupuncture intervention EAE can regulate the secretion of related immune cells and inflammatory factors, alleviate nerve injury and promote nerve rehabilitation. Therefore, in this review, we will retrospect and summarize the recent advances in acupuncture treatment of MS and EAE. So that we can understand the mechanism of acupuncture intervention in MS/EAE better, as well as provide evidence and new perspective for further clinical and scientific research in the future.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - A Review of Acupuncture in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
    AU  - Dong Sha
    AU  - Li Qi
    AU  - Zhao Dongjie
    AU  - Wang Yuhua
    AU  - Xin Suicheng
    Y1  - 2018/12/12
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    N1  - https://doi.org/10.11648/j.sd.20180606.32
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    UR  - https://doi.org/10.11648/j.sd.20180606.32
    AB  - Multiple sclerosis (MS) is considered an incurable inflammatory demyelinating disease of the central nervous system around the world, which damages motor, sensory and autonomic nervous function, and has the characteristics of high recurrence rate and disability rate. Treatment strategy of MS in the world is dominated by glucocorticoid and disease-modify treatments (DMTs). However, due to the shortage of drugs, expensive price, poor response to treatment, obvious side effects and so on, it gradually becomes a common goal of Chinese and Western medicine research, that we must actively explore more effective and optimal treatment strategies to control the recurrence of MS, improve neurological function disability and patient’s quality of life. Clinical reports in recent years have demonstrated that acupuncture has these characteristics of improving neurological disability, reducing fatigue, improving gait abnormality and spasm, alleviating pain, improving bladder function damage, preventing recurrence and improving whole health status in treating MS. It may become a potential ideal complementary and alternative therapy for MS. However, there are relatively few studies on the mechanism of acupuncture treatment of MS and lack of high grade evidence to support it. Undoubtedly, it’s clinical application is limited. Experimental autoimmune encephalomyelitis (EAE) model is a common animal model to study the pathophysiological mechanism of MS and evaluate the efficacy of drugs. Experimental evidences show that acupuncture intervention EAE can regulate the secretion of related immune cells and inflammatory factors, alleviate nerve injury and promote nerve rehabilitation. Therefore, in this review, we will retrospect and summarize the recent advances in acupuncture treatment of MS and EAE. So that we can understand the mechanism of acupuncture intervention in MS/EAE better, as well as provide evidence and new perspective for further clinical and scientific research in the future.
    VL  - 6
    IS  - 6
    ER  - 

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Author Information
  • Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China

  • Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China

  • Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China

  • Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China

  • Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China

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